The reliability of bone marrow cytology as response criterion in metastatic neuroblastoma.

Roswitha Schumacher-KuckelkornAyad AtraMaria Luisa BelliGerda den EngelsmanPaul FréneauxArnaud GauthierAnja Heijlaerts-KleverFrancesca ScuderiLeonor Senent PerisSanjay TewariOndrej ZapletalAngela ErnstFrank Berthold

Published in: Pediatric blood & cancer (2020)

For any work with bone marrow aspirates, the representativity of the material is of paramount importance. A practical definition is proposed. A reliable quantitative cytological assessment of tumor cell content in bone marrow aspirates is not feasible in metastatic neuroblastoma. Therefore, its use as response criterion should be reconsidered.

Keyphrases

bone marrow
mesenchymal stem cells
squamous cell carcinoma
small cell lung cancer
fine needle aspiration
single cell
cell therapy
high grade
high resolution
stem cells
ultrasound guided
mass spectrometry