Rerouting cardiovascular management following gastric bypass surgery: Dose optimization of carvedilol using population-based analysis.
Priscila Akemi YamamotoValvanera VozmedianoRodrigo CristofolettiJinmai JiangThomas D SchmittgenCristiane Masetto de GaitaniRafael KempAjith Kumar SankarankuttyJose Sebastião Dos SantosWilson Salgado JuniorNatalia Valadares De MoraesPublished in: British journal of clinical pharmacology (2024)
Integrated PK/PD modeling indicated that standard dosage regimens for nonoperated subjects do not provide equivalent β-blocking activity in RYGB patients. This study highlights the importance of personalized dosing strategies to attain desired therapeutic outcomes in this patient cohort.
Keyphrases
- gastric bypass
- roux en y gastric bypass
- end stage renal disease
- ejection fraction
- newly diagnosed
- minimally invasive
- chronic kidney disease
- weight loss
- peritoneal dialysis
- prognostic factors
- case report
- type diabetes
- coronary artery bypass
- patient reported outcomes
- coronary artery disease
- percutaneous coronary intervention
- insulin resistance
- acute coronary syndrome
- bariatric surgery
- data analysis