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Characterization of Stable and Reactive Metabolites of the Anticancer Drug, Ensartinib, in Human Liver Microsomes Using LC-MS/MS: An in silico and Practical Bioactivation Approach.

Ali Saber AbdelhameedMohamed W AttwaAdnan A Kadi
Published in: Drug design, development and therapy (2020)
These findings lay the foundations for additional work on ESB toxicity. Substituents to the bioactive centers (piperazine ring), either for blocking or isosteric replacement, would likely block or interrupt hydroxylation reaction that will end the bioactivation sequence.
Keyphrases
  • ms ms
  • molecular docking
  • oxidative stress
  • emergency department
  • drug induced
  • oxide nanoparticles
  • tissue engineering
  • molecular dynamics simulations