Exploring functional protein covariation across single cells using nPOP.

Andrew LeducR Gray HuffmanJoshua CantlonSaad KhanNikolai Slavov

Published in: Genome biology (2022)

nPOP enables flexible, automated, and highly parallelized sample preparation for single-cell proteomics. This allows for quantifying protein covariation across thousands of single cells and revealing functionally concerted biological differences between closely related cell states. Support for nPOP is available at https://scp.slavovlab.net/nPOP .

Keyphrases

single cell
induced apoptosis
cell cycle arrest
high throughput
rna seq
endoplasmic reticulum stress
mass spectrometry
deep learning
stem cells
cell death
oxidative stress
signaling pathway
binding protein
cell proliferation
pi k akt
molecularly imprinted