Three-Membered Aluminacycles.

Three-membered-ring scaffolds of carbocycles, namely, cyclopropanes and cyclopropenes, are ubiquitous in natural products and pharmaceutical molecules. These molecules exhibit a peculiar reactivity, and their applications as synthetic intermediates and versatile building blocks in organic synthesis have been extensively studied over the past century. The incorporation of heteroatoms into three-membered cyclic structures has attracted significant attention, reflecting fundamental differences in their electronic/geometric structures and reactivities compared to their carbon congeners and their associated potential for exploitation in applications. Recently, the chemistry of low-valent aluminum species, alumylenes, dialumenes, and aluminyl anions, has dramatically developed, which has allowed access to hitherto unprecedented aluminacycles. This Perspective focuses upon advances in the chemistry of three-membered aluminacycles, including their synthetic protocols, spectroscopic and structural properties, and reactivity toward various substrates and small molecules.