Identification of Acer2 as a First Susceptibility Gene for Lithium-Induced Nephrogenic Diabetes Insipidus in Mice.

Theun de GrootLena K EbertBirgitte Mønster ChristensenKarolina AndralojcLydie ChevalAlain DoucetCungui MaoRuben BaumgartenBenjamin E LowRoger SandhoffMichael V WilesPeter M T DeenRon Korstanje

Published in: Journal of the American Society of Nephrology : JASN (2019)

We demonstrate that genome-wide association studies in mice can be used successfully to identify susceptibility genes for development of lithium-induced adverse effects. We identified Acer2 as a first susceptibility gene for lithium-induced diabetes insipidus in mice.

Keyphrases

high glucose
diabetic rats
type diabetes
cardiovascular disease
genome wide

high fat diet induced
drug induced
copy number
genome wide identification
genome wide association

glycemic control
gene expression
adipose tissue
metabolic syndrome

weight loss
solid state
bioinformatics analysis
genome wide analysis