Cortical hyperexcitability evolves with disease progression in ALS.

Parvathi MenonMana HigashiharaMehdi van den BosNimeshan GeevasingaMatthew C Kiernan Steve Vucic

Published in: Annals of clinical and translational neurology (2020)

This study established an increase in cortical hyperexcitability with increased disease duration in ALS, mediated by cortical disinhibition and direct increase in corticomotoneuronal excitability.

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