Whole-exome sequencing in a Japanese multiplex family identifies new susceptibility genes for intracranial aneurysms.

Tatsuya MaegawaHiroyuki Akagawa Hideaki OndaHidetoshi Kasuya

Published in: PloS one (2022)

NPNT and CBY2 were identified as novel susceptibility genes for IA. The highly heterogeneous and polygenic architecture of IA susceptibility can be uncovered by accumulating extensive analyses that focus on each pedigree with a high incidence of IA.

Keyphrases

genome wide
bioinformatics analysis
dna methylation
genome wide identification
gene expression
high throughput
genome wide analysis