Renal Mitochondrial ATP Transporter Ablation Ameliorates Obesity-Induced Chronic Kidney Disease.
Anna PermyakovaSharleen HamadLiad HindenSaja BaraghithyAviram Kogot-LevinOmri YosefOri ShalevManish Kumar TripathiHaitham AmalAbhishek BasuMuhammad ArifResat CinarGeorge KunosMichael BergerGil LeibowitzJoseph TamPublished in: Journal of the American Society of Nephrology : JASN (2024)
We propose a significant role for RPTC-Ant2 in the development of obesity-induced CKD. The nullification of RPTC-Ant2 triggers a cascade of cellular mechanisms, including mitochondrial protection, enhanced RPTC survival, and ultimately the preservation of kidney function. These findings shed new light on the complex metabolic pathways contributing to CKD development and suggest potential therapeutic targets for this condition.
Keyphrases
- chronic kidney disease
- end stage renal disease
- oxidative stress
- metabolic syndrome
- high glucose
- insulin resistance
- diabetic rats
- weight loss
- type diabetes
- weight gain
- drug induced
- endothelial cells
- skeletal muscle
- atrial fibrillation
- mouse model
- climate change
- body mass index
- radiofrequency ablation
- free survival
- stress induced