Polymer Lung Surfactants Attenuate Direct Lung Injury in Mice.
Daniel J FesenmeierMadathilparambil V SureshSeyoung KimSungwan ParkKrishnan RaghavendranYou-Yeon WonPublished in: ACS biomaterials science & engineering (2023)
If not properly managed, acute lung injuries, either through direct or indirect causes, have the potential to present serious risk for many patients worldwide. One of the mechanisms for the transition from acute lung injury (ALI) to the more serious acute respiratory distress syndrome (ARDS) is the deactivation of the native lung surfactant by injury-induced infiltrates to the alveolar space. Currently, there are no surfactant replacement therapies that are used to treat ALI and subsequent ARDS. In this paper, we present an indepth efficacy study of using a novel polymer lung surfactant (PLS, composed of poly(styrene- block -ethylene glycol) (PS-PEG) block copolymer micelles), which has unique properties compared to other tested surfactant replacements, in two different mouse models of lung injury. The results demonstrate that pharyngeal administration of PLS after the instillation of either acid (HCl) or lipopolysaccharide (LPS) can decrease the severity of lung injury as measured by multiple injury markers.
Keyphrases
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- mechanical ventilation
- drug delivery
- end stage renal disease
- inflammatory response
- ejection fraction
- chronic kidney disease
- lipopolysaccharide induced
- newly diagnosed
- drug release
- prognostic factors
- mouse model
- cancer therapy
- diabetic rats
- endothelial cells
- toll like receptor
- anti inflammatory
- metabolic syndrome
- oxidative stress
- hepatitis b virus
- peritoneal dialysis
- insulin resistance