Persistent Hyperinsulinemia Following High-Dose Insulin Therapy: A Case Report.
Justin N CorcoranKatherine J JacobyTravis D OlivesStacey A BanghJon B ColePublished in: Journal of medical toxicology : official journal of the American College of Medical Toxicology (2020)
The kinetics of insulin following discontinuation of high-dose insulin therapy are largely unknown, but supraphysiologic insulin levels persist for some time following therapy; this may allow for simple discontinuation rather than titration of insulin at the end of therapy. Dextrose replacement is frequently needed; although the duration is often difficult to predict, prolonged infusions may not be necessary.