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Virus-like particle vaccine displaying an external, membrane adjacent MUC16 epitope elicits ovarian cancer-reactive antibodies.

Hsin-Fang TuMargaret WongSsu-Hsueh TsengNattha IngavatPola OlczakKin Israel NotarteChien-Fu HungRichard B S Roden
Published in: Journal of ovarian research (2024)
Vaccination with VLP displaying the 20 aa juxta-membrane MUC16 ectodomain, which includes the membrane proximal cleavage site, is likely to be well tolerated and induce IgG targeting ovarian cancer cells, even after CA125 is shed.
Keyphrases
  • cancer therapy
  • dna binding
  • drug delivery
  • transcription factor