Application of 89 Zr-DFO*-immuno-PET to assess improved target engagement of a bispecific anti-amyloid-ß monoclonal antibody.

N StergiouT E WuenscheM SchreursI MesM VerlaanE J M KooijmanA D WindhorstL HelboeS VergoS ChristensenA A AsuniA JensenG A M S Van DongenB Bang-AndersenD J VugtsWissam Beaino

Published in: European journal of nuclear medicine and molecular imaging (2023)

Zr-DFO*-immuno-PET can be used to visualize and quantify brain uptake of mAbs and contribute to the evaluation of biological therapeutics for brain diseases.

Keyphrases

pet imaging
monoclonal antibody
resting state
white matter
positron emission tomography
pet ct
computed tomography
functional connectivity
small molecule
cerebral ischemia
social media
blood brain barrier