Invasive growth of brain metastases is linked to CHI3L1 release from pSTAT3-positive astrocytes.

Matthew DanknerSarah M MaritanNeibla PriegoGeorgia KruckAndriniaina Nkili-MeyongJavad NadafRebecca ZhuangMatthew G AnnisDongmei ZuoAlexander NowakowskiMarco BiondiniAlexander KiepasCaitlyn MourcosPhuong LeFrançois CharronYanis InglebertPaul SavageLouis ThéretMarie-Christine GuiotR Anne McKinneyWilliam J MullerMorag ParkManuel ValienteKevin PetreccaPeter M Siegel

Published in: Neuro-oncology (2024)

Together, these data reveal that pSTAT3+ RA-derived CHI3L1 is associated with BrM invasion, implicating STAT3 and CHI3L1 as clinically relevant therapeutic targets for the treatment of HI BrM.

Keyphrases

brain metastases
small cell lung cancer
rheumatoid arthritis
genome wide
electronic health record
cell migration
big data
single cell
gene expression
disease activity
dna methylation
systemic lupus erythematosus
artificial intelligence