Hidradenitis suppurativa associated telomere-methylome dysregulations in blood.
Uppala RadhakrishnaUppala RatnamalaDevendrasinh D JhalaLavanya V UppalaAaren VedangiNazia SaiyedMaulikkumar PatelNikita VadsariaSushma R ShahRakesh M RawalSanto R MercuriDennis McGonagleGregor B E JemecGiovanni DamianiPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2023)
The disruption of TRGs leads to the shortening of telomeres, which is associated with HS progression, aging, cellular senescence, and an increased risk of various diseases, including cancer and associated comorbidities, such as metabolic syndrome, cardiovascular disease, and inflammatory disorders. Further research is necessary to better understand the underlying mechanisms and establish causal links between TRGs and HS. The present study is the first effort to comprehend potential pathomechanisms of sporadic HS cases concentrating on PBMC methylome since ours.
Keyphrases
- hidradenitis suppurativa
- metabolic syndrome
- cardiovascular disease
- papillary thyroid
- dna damage
- endothelial cells
- type diabetes
- insulin resistance
- oxidative stress
- late onset
- squamous cell
- cardiovascular risk factors
- coronary artery disease
- uric acid
- stress induced
- risk assessment
- human health
- adipose tissue
- amyotrophic lateral sclerosis
- lymph node metastasis
- skeletal muscle
- childhood cancer