Adaptive trial designs for spinal cord injury clinical trials directed to the central nervous system.
Mary Jane MulcaheyLinda A T JonesFrank W RockholdRϋediger RuppJohn L K KramerSteven KirshblumAndrew BlightDaniel LammertseJames D GuestJohn D SteevesPublished in: Spinal cord (2020)
Although successfully applied in other fields, adaptive clinical trial designs in SCI clinical trial programs have been narrow in scope and few in number. Immediate application of several adaptive methods offers opportunity to improve efficiency of SCI trials. Concerted effort is needed by all stakeholders to advance adaptive clinical trial design methodology in SCI.