Lung Transplantation for Adult Respiratory Distress Syndrome after SARS-CoV-2 Infection.
Achim KochNikolaus PizanisVasiliki BessaFrank HerbstreitErich GulbinsClemens AignerMarkus KamlerPublished in: The Thoracic and cardiovascular surgeon reports (2022)
Background The majority of patients with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection present mild symptoms. However, some patients develop severe acute respiratory distress syndrome (ARDS) and subsequent irreversible lung damage despite extracorporeal membrane oxygenation, leaving lung transplantation the ultimate therapeutically option. Case Description Here, we report a case of lung transplantation in a 31-year-old male recipient suffering from post-coronavirus disease 2019 respiratory failure with irreversible ARDS after prolonged extracorporeal membrane oxygenation therapy. Conclusion Patient selection criteria are elucidated. One relevant mechanism for susceptibility to SARS-CoV-2 in the respiratory system, the acid sphingomyelinase/ceramide system might be altered during infection with SARS-CoV-2.
Keyphrases
- extracorporeal membrane oxygenation
- respiratory syndrome coronavirus
- acute respiratory distress syndrome
- sars cov
- respiratory failure
- coronavirus disease
- mechanical ventilation
- end stage renal disease
- ejection fraction
- chronic kidney disease
- newly diagnosed
- prognostic factors
- oxidative stress
- early onset
- patient reported outcomes
- stem cells
- depressive symptoms
- smoking cessation
- sleep quality
- childhood cancer