IgE antibody repertoire in nasal secretions of children and adults with seasonal allergic rhinitis: A molecular analysis.
Sveva CastelliStefania ArasiSalvatore TripodiDanilo VillaltaPaola MartelliMariaelisabetta ConteValentina PanettaIlaria SimonelliAlexander RohrbachMarco Di FraiaIfigenia SfikaValeria VillellaAndrea Di Rienzo BusincoSerena PernaStephanie DramburgEkaterina PotapovaPaolo Maria MatricardiPublished in: Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology (2020)
The concentration of sIgE is much lower in nasal secretions than in the serum. sIgE assays with very high analytical sensitivity and sampling methods with minimal dilution will be therefore needed to validate nasal secretions as alternative to serum in testing the sIgE repertoire.