Implications of Off-Target Serotoninergic Drug Activity: An Analysis of Serotonin Syndrome Reports Using a Systematic Bioinformatics Approach.

Vaughn L CulbertsonShaikh E RahmanGrayson C BosenMatthew L CaylorMegan M EchevarriaDong Xu

Published in: Pharmacotherapy (2018)

The SEBM model suggests a possible polypharmacological role in SS. Although further research is needed, off-target receptor activity may help explain differences in severity of toxicity and clinical presentation.

Keyphrases

adverse drug
oxidative stress