0.6 V, 116 nW Neural Spike Acquisition IC with Self-Biased Instrumentation Amplifier and Analog Spike Extraction.

This paper presents an ultralow power 0.6 V 116 nW neural spike acquisition integrated circuit with analog spike extraction. To reduce power consumption, an ultralow power self-biased current-balanced instrumentation amplifier (IA) is proposed. The passive RC lowpass filter in the amplifier acts as both DC servo loop and self-bias circuit. The spike detector, based on an analog nonlinear energy operator consisting of a low-voltage open-loop differentiator and an open-loop gate-bulk input multiplier, is designed to emphasize the high frequency spike components nonlinearly. To reduce the spike detection error, the adjacent spike merger is also proposed. The proposed circuit achieves a low IA current consumption of 46.4 nA at 0.6 V, noise efficiency factor (NEF) of 1.81, the bandwidth from 102 Hz to 1.94 kHz, the input referred noise of 9.37 μVrms, and overall power consumption of 116 nW at 0.6 V. The proposed circuit can be used in the ultralow power spike pulses acquisition applications, including the neurofeedback systems on peripheral nerves with low neuron density.