Association of polymorphism c.-124G>A and c.-16 C>T in the promoter region of human INHA gene with altered sperm parameters; A pilot study.

Wardah RafaqatMuhammad Rohan KayaniTasneem FatimaSaeeda ShaharyarShagufta KhanMussarat AshrafUsman AfzalRehana Rehman

Published in: International journal of clinical practice (2020)

The results from our study exhibited a significant association of c.-124G>A polymorphism in the INHα gene promoter region with male infertility in the Pakistani population. A significant association of c.-16 C>T polymorphism with male infertility, however, was not observed. Further large-scale studies should be conducted to confirm this association.

Keyphrases

dna methylation
gene expression
endothelial cells

transcription factor
genome wide
copy number

type diabetes
adipose tissue
metabolic syndrome

skeletal muscle
genome wide identification
induced pluripotent stem cells