An anti-mesothelin targeting antibody drug conjugate induces pyroptosis and ignites antitumor immunity in mouse models of cancer.

Nicole L WittwerAlexander H StaudacherVasilios LiapisPina CardarelliHarriet WarrenMichael P Brown

Published in: Journal for immunotherapy of cancer (2023)

Together, these results show for the first time that tubulysin and a tubulysin containing ADC can elicit pyroptosis, and that this fiery cell death is critical for antitumor immunity and therapeutic response.

Keyphrases

cell death
nlrp inflammasome
cancer therapy
papillary thyroid
mouse model
squamous cell
cell cycle arrest
diffusion weighted
drug delivery
lymph node metastasis
squamous cell carcinoma
diffusion weighted imaging
magnetic resonance
signaling pathway