Assessment of de novo copy-number variations in Italian patients with schizophrenia: Detection of putative mutations involving regulatory enhancer elements.

Giulio PilusoPalmiero MonteleoneSilvana GalderisiTeresa GiuglianoAlessandro BertolinoPaola RoccaAlessandro RossiArmida MucciEugenio AgugliaIleana AndriolaAntonello BellomoAnna ComparelliFrancesco GambiAndrea FagioliniCarlo MarchesiRita RonconeEmilio SacchettiPaolo SantonastasoAlberto SiracusanoPaolo StrattaAlfonso TortorellaLuca SteardoPaola BucciVincenzo NigroMario Majnull null

Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2017)

These findings provide further evidence for the involvement of de novo CNVs in the pathogenesis of schizophrenia and suggest that CNVs affecting regulatory enhancer elements could contribute to the genetic vulnerability to the disorder.

Keyphrases

copy number
transcription factor
mitochondrial dna
genome wide
binding protein
bipolar disorder
dna methylation
climate change
loop mediated isothermal amplification
label free
real time pcr