Genetic susceptibility to nonalcoholic fatty liver disease and risk for pancreatic cancer: Mendelian randomization.
Sontoria D KingSwathi VeligintiMartijn C G J BrouwersZhewen RenQuan LongVeronica Wendy SetiawanLynne R WilkensChristina E BaileyAlan A ArslanLaura E Beane-FreemanPaige M BracciFrederico CanzianMengmeng DuSteven J GallingerGraham G GilesPhyllis J GoodmanChristopher A HaimanManolis KogevinasCharles KooperbergLoic Le MarchandRachel E NealeKala VisvanathanEmily WhiteDemetrios AlbanesGabriella AndreottiAna BabicSonja I BerndtLauren K BraisPaul J BrennanJulie E BuringKari G RabeWilliam R BamletStephen J ChanockCharles S FuchsJohn Michael GazianoEdward L GiovannucciThilo HackertManal M HassanVerena A KatzkeRobert C KurtzI-Min LeeNúria MalatsNeil MurphyAnn L ObergIrene OrlowMiquel PortaFrancisco X RealNathaniel RothmanHoward D SessoDebra T SilvermanIan M ThompsonJean Wactawski-WendeXiaoliang WangNicolas WenstzensenHerbert YuAnne Zeleniuch-JacquotteKai YuBrian M WolpinEric Jeffrey DuellDounghui LiRayjean J HungSandra PerdomoMarjorie L McCulloughNeal D FreedmanAlpa V PatelUlrike PetersElio RiboliMalin SundAnne TjønnelandJun ZhongStephen K Van den EedenPeter KraftHarvey A RischLaufey T AmundadottirAlison P KleinRachael Z Stolzenberg-SolomonSamuel O AntwiPublished in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2023)
Given the close relationship between NAFLD and metabolic conditions, it is plausible that any association between NAFLD and PC might reflect host metabolic perturbations (e.g., obesity, diabetes, or metabolic syndrome) and does not necessarily reflect a causal relationship between NAFLD and PC.