Acute leukemia with cytogenetically cryptic FGFR1 rearrangement and lineage switch during therapy: A case report and literature review.

Sean J McKeagueKacey O'RourkeStephen FanningChristopher JoyDuncan ThropRebecca AdamsYasmin HarveyTee Beng Keng

Published in: American journal of clinical pathology (2023)

Ours is the only reported case of FGFR1-rearranged neoplasms with a disease sequence of acute myeloid leukemia transforming to B-cell acute lymphoblastic leukemia and 1 of only 3 reported cases with cytogenetically cryptic FGFR1 rearrangement. Fluorescence in situ hybridization testing for FGFR1 rearrangement should be a standard investigation in leukemia of mixed or switching lineage.

Keyphrases

acute myeloid leukemia
acute lymphoblastic leukemia
allogeneic hematopoietic stem cell transplantation
single cell
bone marrow
stem cells
single molecule
mesenchymal stem cells
amino acid
cell fate
quantum dots
energy transfer
replacement therapy
chemotherapy induced