Cell-Free DNA Derived From Neutrophils Triggers Type 1 Interferon Signature in Neuromyelitis Optica Spectrum Disorder.
Hisashi MurataMakoto KinoshitaYoshiaki YasumizuDaisuke MotookaShohei BeppuNaoyuki ShiraishiYasuko SugiyamaKeigo KiharaSatoru TadaToru KodaHachiro KonakaHyota TakamatsuAtsushi KumanogohTatsusada OkunoHideki MochizukiPublished in: Neurology(R) neuroimmunology & neuroinflammation (2022)
Our study highlights the previously unrevealed role of cfDNA predominantly released by neutrophil in the induction of IFN-1 signature in NMOSD and further indicate a novel pharmacologic target in NMOSD.