In vivo monitoring of dynamic interaction between neutrophil and human umbilical cord blood-derived mesenchymal stem cell in mouse liver during sepsis.

Sung Yong AhnYong-Sun MaengYu Rim KimYoung Ho ChoeHan Sung HwangYoung-Min Hyun

Published in: Stem cell research & therapy (2020)

These distinct interaction patterns between innate immune cells and hUCB-MSCs demonstrated that hUCB-MSCs have beneficial effects against LPS-induced sepsis through associations with neutrophils. In addition, the immunomodulatory properties of hUCB-MSCs might enable immune evasion in the host. Taken together, our results suggest the prospects of hUCB-MSCs as a therapeutic tool to inhibit inflammation and alleviate pathological immune responses such as sepsis.

Keyphrases

mesenchymal stem cells
umbilical cord
lps induced
cord blood
septic shock
acute kidney injury
innate immune
intensive care unit
immune response
inflammatory response
bone marrow
induced apoptosis
oxidative stress
cell therapy
current status
stem cells
cell death
endoplasmic reticulum stress