Synthesis of a Reactive Oxygen Species-Responsive Doxorubicin Derivative.

James B DelehantyShivani DasEfram GoldbergAjmeeta SangtaniD Andrew Knight

Published in: Molecules (Basel, Switzerland) (2018)

A heterobifunctional reactive oxygen species (ROS)-responsive linker for directed drug assembly onto and delivery from a quantum dot (QD) nanoparticle carrier was synthesized and coupled to doxorubicin using N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (EDC)/sulfo⁻NHS coupling. The doxorubicin conjugate was characterized using ¹H NMR and LC-MS and subsequently reacted under conditions of ROS formation (Cu2+/H₂O₂) resulting in successful and rapid thioacetal oxidative cleavage, which was monitored using ¹H NMR.

Keyphrases

reactive oxygen species
cancer therapy
drug delivery
magnetic resonance
high resolution
solid state
emergency department
dna binding
cell death
oxidative stress
adverse drug
loop mediated isothermal amplification
quality improvement