Trophoblasts promote induction of a regulatory phenotype in B cells that can protect against detrimental T cell-mediated inflammation.
Ruth Marian Guzman-GenuinoTanya DimovaYuan YouPaulomi AldoJohn D HayballGil MorKerrilyn R DienerPublished in: American journal of reproductive immunology (New York, N.Y. : 1989) (2019)
We posit that trophoblast-mediated education of B cells leads to their acquisition of properties capable of modulating inflammation in the uterine environment during the peri-implantation period.