Acetylated HOXB13 Regulated Super Enhancer Genes Define Therapeutic Vulnerabilities of Castration-Resistant Prostate Cancer.

Duy T Nguyen Wei Yang Arun Renganathan Cody Weimholt Duminduni H Angappulige Thanh Nguyen Robert W Sprung Gerald L Andriole Eric H Kim Nupam P Mahajan Kiran Mahajan

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2022)

In summary, acetylated HOXB13 is a biomarker of clinically significant prostate cancer. Importantly, PSMA-targeting agents and (R)-9b could be new therapeutic modalities to target HOXB13-ACK1 axis regulated prostate cancers.

Keyphrases

prostate cancer
transcription factor
radical prostatectomy
pet ct
pet imaging
genome wide identification
gene expression
computed tomography
dna methylation
drug delivery
positron emission tomography
genome wide analysis