Mitochondrial regulation of acute extrafollicular B-cell responses to COVID-19 severity.

Tianyu CaoLi LiuKelvin Kai-Wang ToChun-Yu LimRunhong ZhouYue MingKa-Yi KwanSulan YuChun-Yin ChanBiao ZhouHaode HuangYufei MoZhenglong DuRuomei GongLuk-Tsz YatIvan Fan-Ngai HungAnthony Raymond TamWing-Kin ToWai-Shing LeungThomas Shiu-Hong ChikOwen Tak-Yin TsangXiang LinYou-Qiang SongKwok-Yung YuenZhiwei Chen

Published in: Clinical and translational medicine (2022)

Our results reveal an immune mechanism that controls SARS-CoV-2-induced detrimental B cell responses and COVID-19 severity, which may have implications for viral pathogenesis, therapeutic interventions and vaccine development.

Keyphrases

sars cov
respiratory syndrome coronavirus
drug induced
coronavirus disease
liver failure
oxidative stress
diabetic rats
high glucose
physical activity
respiratory failure
single cell
gene expression
aortic dissection
intensive care unit
endothelial cells