Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis.
Fabiana Antunes DE AndradeIsabela Goeldner EibofnerCristhine PieczarkaHoang van TongLeia SenaThelma SkareShirley Ramos da Rosa UtiyamaIara Jose de Messias-ReasonThirumalaisamy P VelavanPublished in: International journal of immunogenetics (2021)
The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.
Keyphrases
- rheumatoid arthritis
- gene expression
- disease activity
- induced apoptosis
- dna methylation
- interstitial lung disease
- polycystic ovary syndrome
- cell cycle arrest
- genome wide
- copy number
- stem cells
- cell therapy
- pregnant women
- systemic lupus erythematosus
- endoplasmic reticulum stress
- binding protein
- signaling pathway
- cell proliferation
- drug induced