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Impact of VSIG4 gene polymorphisms on susceptibility and functional status of rheumatoid arthritis.

Fabiana Antunes DE AndradeIsabela Goeldner EibofnerCristhine PieczarkaHoang van TongLeia SenaThelma SkareShirley Ramos da Rosa UtiyamaIara Jose de Messias-ReasonThirumalaisamy P Velavan
Published in: International journal of immunogenetics (2021)
The complement receptor of the immunoglobulin superfamily (CRIg, encoded by the VSIG4 gene) is a macrophage receptor involved in the clearance of immune complexes and autologous cells. Our results suggest that the VSIG4 rs1044165T allele is a risk factor for severe functional status of rheumatoid arthritis in women, possibly by affecting VSIG4 gene expression.
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