Clinical and Laboratory Features of 184 Italian Pediatric Patients Affected with Selective IgA Deficiency (SIgAD): a Longitudinal Single-Center Study.
Vassilios LougarisAnnamaria SorliniChiara MonfrediniGiulia IngrasciottaAndrea CaravaggioTiziana LorenziniManuela BaronioMarco CattaliniAntonella MeiniLaura RuggeriAnnamaria SalpietroAlba PilottaLivia GrazzaniElena PrandiBarbara FelappiGiulio GualdiAntonella FabianoMaurizio FuotiAlberto RavelliVincenzo VillanacciAnnarosa SoresinaRaffaele BadolatoAlessandro PlebaniPublished in: Journal of clinical immunology (2019)
In conclusion, this is the first study to describe a large single-center pediatric cohort of patients affected with SIgAD, revealing that overall most patients do well with regard to infections. Many develop CD, at a rate much higher than the general population. A few normalize their IgA levels. A few progress to CVID. Thus, careful follow-up is suggested to diagnose and treat potential complications earlier for avoiding potential morbidities.