KCa3.1 Promotes Proinflammatory Exosome Secretion by Activating AKT/Rab27a in Atrial Myocytes during Rapid Pacing.

Dishiwen LiuHuiyu ChenYuntao FuYajun YaoShanqing HeYoucheng WangZhen CaoXuewen WangMei Yang Qingyan Zhao

Published in: Cardiovascular therapeutics (2023)

KCa3.1 promotes proinflammatory exosome secretion through the AKT/Rab27a signaling pathway. Inhibiting the KCa3.1/AKT/Rab27a signaling pathway reduces myocardial tissue structural remodeling in AF.

Keyphrases

signaling pathway
pi k akt
induced apoptosis
epithelial mesenchymal transition
atrial fibrillation
left ventricular
cell proliferation
mitral valve
cardiac resynchronization therapy
left atrial