E-cadherin is downregulated in benign prostatic hyperplasia and required for tight junction formation and permeability barrier in the prostatic epithelial cell monolayer.
Feng LiLaura E PascalDonna B StolzKe WangYibin ZhouWei ChenYadong XuYule ChenRajiv DhirAnil V ParwaniJoel B NelsonDonald B DeFrancoNaoki YoshimuraGoundappa K BalasubramaniJeffrey R GingrichJodi K MaranchieBruce L JacobsBenjamin J DaviesRonald L HrebinkoJoel D BigleyDawn McBridePeng GuoDalin HeZhou WangPublished in: The Prostate (2019)
Our results indicate that tight junctions are compromised in BPH and loss of E-cadherin is potentially an important underlying mechanism, suggesting targeting E-cadherin loss could be a potential approach to prevent or treat BPH.