Statin-Induced Nitric Oxide Signaling: Mechanisms and Therapeutic Implications.
Armita Mahdavi GorabiNasim KiaieSaeideh HajighasemiMaciej BanachPeter E PensonTannaz JamialahmadiAmirhossein SahebkarPublished in: Journal of clinical medicine (2019)
In addition to their cholesterol-lowering effects, statins are associated with pleiotropic effects including improvements in heart failure (HF), reduced blood pressure, prevention of the rupture of atherosclerotic plaques and improved angiogenesis. In addition to these cardiovascular benefits, statins have been implicated in the treatment of neurological injuries, cancer, sepsis, and cirrhosis. These cholesterol-independent beneficial effects of statins are predominantly mediated through signaling pathways leading to increased production and bioavailability of nitric oxide (NO). In this review, the mechanistic pathways and therapeutic effects of statin-mediated elevations of NO are described and discussed.
Keyphrases
- nitric oxide
- cardiovascular disease
- low density lipoprotein
- heart failure
- blood pressure
- coronary artery disease
- hydrogen peroxide
- nitric oxide synthase
- intensive care unit
- squamous cell carcinoma
- type diabetes
- left ventricular
- endothelial cells
- oxidative stress
- heart rate
- papillary thyroid
- vascular endothelial growth factor
- squamous cell
- young adults
- epithelial mesenchymal transition
- septic shock
- pi k akt
- brain injury
- blood glucose
- wound healing
- subarachnoid hemorrhage
- weight loss
- african american
- cerebral ischemia