Escape from cell-cell and cell-matrix adhesion dependence underscores disease progression in gastric cancer organoid models.
Yin TongPriscilla S W ChengChung Sze OrSarah S K YueHoi Cheong SiuSiu Lun HoSimon Y K LawWai Yin TsuiDessy ChanStephianie MaSiu Po LeeAnnie S Y ChanApril S ChanShui Wa YunHo Sang HuiSiu Tsan YuenSuet Yi LeungHelen H N YanPublished in: Gut (2022)
The CCi/CMi phenotype has a critical role in malignant transformation and tumour progression, offering new mechanistic information on RHO-ROCK pathway inhibition that contributes to GC pathogenicity.