Defining the dose-volume criteria for laryngeal sparing in locally advanced oropharyngeal cancer utilizing split-field IMRT, whole-field IMRT and VMAT.
Christopher WilkeVinita TakiarHe WangAmy C MorenoShih-Ming Samuel TungSean R Quinlan-DavidsonAdam S GardenDavid I RosenthalClifton D FullerGary B GunnJay P ReddyWilliam H MorrisonCongjun WangGeorge ZhaoKatherine A HutchesonJack PhanPublished in: Journal of applied clinical medical physics (2020)
We evaluated laryngeal dose in patients with locally advanced oropharyngeal cancer treated to the bilateral neck using split-field IMRT (SF-IMRT), whole-field IMRT (WF-IMRT) and volumetric arc therapy (VMAT). All three techniques provided good sparing of laryngeal structures and were able to achieve a mean larynx dose < 33 Gy. There were no significant differences in dose to target structures or non-laryngeal organs at risk among techniques.
Keyphrases
- locally advanced
- papillary thyroid
- squamous cell carcinoma
- rectal cancer
- neoadjuvant chemotherapy
- squamous cell
- robot assisted
- high resolution
- radiation therapy
- stem cells
- clinical trial
- young adults
- childhood cancer
- case report
- mesenchymal stem cells
- bone marrow
- study protocol
- replacement therapy
- smoking cessation
- open label
- double blind