Diaporchalasins A-E, New Cytochalasins from the Endophytic Fungus Diaporthe sp. BMX12 Isolated from Aquilaria sinensis.
Li YangQi WangQing-Yun MaQing-Yi XieCui-Juan GaiYou-Gen WuHao-Fu DaiYou-Xing ZhaoPublished in: Chemistry & biodiversity (2024)
Five new cytochalasins, diaporchalasins A-E (1-5), together with 14 known congeners (6-19) were isolated from the endophytic fungus Diaporthe sp. BMX12, which was isolated from the branches of Aquilaria sinensis. The structures of the new compounds were elucidated by extensive spectroscopic analyses including high-resolution electron spray ionization mass spectrometry (HR-ESI-MS) and nuclear magnetic resonance (NMR). Their absolute configurations were assigned by theoretical electronic circular dichroism (ECD) calculations. Compounds 11 and 12 featuring a keto carbonyl at C-21 displayed cytotoxicity toward K562, BEL-7402, SGC-7901, A549, and HeLa cell lines with IC 50 values ranging from 4.4 to 47.4 μM.
Keyphrases
- high resolution
- mass spectrometry
- magnetic resonance
- gas chromatography
- ms ms
- liquid chromatography
- capillary electrophoresis
- molecular docking
- high performance liquid chromatography
- tandem mass spectrometry
- molecular dynamics
- density functional theory
- molecular dynamics simulations
- multiple sclerosis
- solid state
- cell death
- signaling pathway