Severe Obesity in Women Can Lead to Worse Memory Function and Iron Dyshomeostasis Compared to Lower Grade Obesity.

Jessica M V Pino Vitória F Silva Marcos Mônico-Neto Danielle C Seva Melissa Y Kato July N Alves Gabriela Cruz PereiraHanna Karen M AntunesThales D GalvaoLia R A BitterncourtSergio TufikLysien I ZambranoAna R DâmasoLila M OyamaDavid ThivelRaquel Munhoz da Silveira Campos Kil Sun Lee

Published in: International journal of endocrinology (2023)

Iron is an essential micronutrient for several metabolic pathways. Thus, iron dyshomeostasis observed in severe obesity may aggravate the cognitive impairment by altering metabolic homeostasis and enhancing oxidative stress. These findings can contribute to searching for biomarkers that indicate cognitive performance in the population with obesity.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
oxidative stress
cognitive impairment
polycystic ovary syndrome
early onset
skeletal muscle
body mass index
ischemia reperfusion injury
dna damage
working memory