Shed antigen-induced blocking effect on CAR-T cells targeting Glypican-3 in Hepatocellular Carcinoma.

Luan SunFang GaoZhanhui GaoLei AoNa LiSujuan MaMeng JiaNan LiPeihua LuBeicheng SunMitchell HoShaochang JiaTong DingWei Gao

Published in: Journal for immunotherapy of cancer (2021)

We provide a proof-of-concept study demonstrating that GPC3 shedding might cause worse response to CAR-T cell treatment by competing with cell surface GPC3 for CAR-T cell binding, which revealed a new mechanism of tumor immune escape in HCC, providing a novel biomarker for patient enrolment in future clinical trials and/or treatments with GPC3-targeted CAR-T cells.

Keyphrases

cell surface
clinical trial
cancer therapy
case report
oxidative stress
open label
combination therapy
replacement therapy