Tumor Platinum Concentrations and Pathological Responses Following Cisplatin-Containing Chemotherapy in Gastric Cancer Patients.
Yanshuo CaoQing ChangMichael CabaneroWenjiang ZhangSara Hafezi-BakhtiariDavid HedleyGail DarlingFayez QuereshyRaymond JangElena ElimovaJennifer KnoxOlga OrnatskyStefano SerraEric X ChenPublished in: Journal of gastrointestinal cancer (2020)
Platinum was detectable in surgical specimens up to 72 days after preoperative chemotherapy. Higher tumor platinum concentration correlated with improved pathological response. Collagen binding potentially explained the high interpatient variability in tumor platinum concentrations.