Highly dampened blood transcriptome response in HIV patients after influenza infection.
Subhashini A SellersWilliam A FischerMark T HeiseKlaus SchughartPublished in: Scientific reports (2021)
Respiratory viral (RV) infections represent a major threat for human health worldwide. Persons with HIV (PWH) have a compromised immune response and are thought to be at higher risk for severe RV disease. However, very little is known about the host immune response to RV infection in PWH. Here, we investigated gene expression changes in the peripheral blood of PWH co-infected with RV. Only very few differentially expressed genes could be detected between PWH with and without RV infection, suggesting that the immune response to RV in PWH is strongly dampened. Our data provides important insights into the host response to RV infections in HIV patients.
Keyphrases
- mycobacterium tuberculosis
- gene expression
- end stage renal disease
- antiretroviral therapy
- hiv positive
- immune response
- hiv infected
- human immunodeficiency virus
- ejection fraction
- hepatitis c virus
- human health
- newly diagnosed
- chronic kidney disease
- hiv testing
- hiv aids
- peripheral blood
- risk assessment
- peritoneal dialysis
- prognostic factors
- dna methylation
- sars cov
- genome wide
- men who have sex with men
- machine learning
- patient reported outcomes
- big data
- dendritic cells
- single cell
- toll like receptor