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SUMO E3 Ligase PIASy Mediates High Glucose-Induced Activation of NF-κB Inflammatory Signaling in Rat Mesangial Cells.

Wei HuangYaling LiangJianhua DongLuping ZhouChenlin GaoChunxia JiangMeijuan ChenYang LongYong Xu
Published in: Mediators of inflammation (2017)
The SUMO E3 ligase PIASy mediates high glucose-induced activation of NF-κB inflammatory signaling, suggesting that PIASy may be a potential therapeutic target of DN.
Keyphrases
  • high glucose
  • endothelial cells
  • oxidative stress
  • signaling pathway
  • induced apoptosis
  • lps induced
  • pi k akt
  • nuclear factor
  • cell cycle arrest
  • diabetic rats
  • risk assessment
  • inflammatory response