Interplay between low plasma RANKL and VDR-FokI polymorphism in lumbar disc herniation independently from age, body mass, and environmental factors: a case-control study in the Italian population.

Veronica SansoniSilvia PeregoAlessandra ColombiniGiuseppe BanfiMarco Brayda-BrunoGiovanni Lombardi

Published in: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society (2015)

Whether vertebral bone changes precede or follow cartilage deterioration in intervertebral disc degeneration is not known. Our results suggest a reduced bone turnover rate, associated to a specific genetic background, in patients affected by lumbar disc herniation which could be one of the favoring factors for disc degeneration.

Keyphrases

bone mineral density
end stage renal disease
minimally invasive
postmenopausal women
bone loss
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
soft tissue
dna methylation
bone regeneration
copy number
nuclear factor
toll like receptor