Multi-Drug Cocktail Therapy Improves Survival and Neurological Function after Asphyxial Cardiac Arrest in Rodents.
Rishabh C ChoudharyMuhammad ShoaibKei HayashidaTai YinSantiago J MiyaraCristina d'AbramoWilliam G HeuserKoichiro ShinozakiNancy KimRyosuke TakegawaMitsuaki NishikimiTimmy LiCasey OwensErnesto P MolmentiMingzhu HeSonya VanpattenYousef Al-AbedJunhwan KimLance B BeckerPublished in: Cells (2023)
Our findings demonstrate that, with its ability to target multiple damaging pathways, a multi-drug therapeutic cocktail offers promise both as a conceptual advance and as a specific multi-drug formulation capable of combatting neuronal degeneration and death following cardiac arrest. Clinical implementation of this therapy may improve neurologically favorable survival rates and neurological deficits in patients suffering from cardiac arrest.
Keyphrases
- cardiac arrest
- cardiopulmonary resuscitation
- end stage renal disease
- primary care
- ejection fraction
- newly diagnosed
- chronic kidney disease
- healthcare
- traumatic brain injury
- adverse drug
- cerebral ischemia
- patient reported outcomes
- stem cells
- drug delivery
- emergency department
- cell therapy
- drug induced
- machine learning
- free survival
- subarachnoid hemorrhage
- mesenchymal stem cells
- smoking cessation