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Gold(I)-catalysed hydroarylations of alkynes for the synthesis of inherently chiral calix[4]arenes.

Gabriele GiovanardiGabriele ScaricaValentina PirovanoAndrea SecchiGianpiero Cera
Published in: Organic & biomolecular chemistry (2023)
We describe the first gold(I)-catalysed intramolecular hydroarylation of alkynes for the straightforward synthesis of inherently chiral calix[4]arenes. This step- and atom-economical approach, which exploits a formal meta -functionalisation of the calix[4]arene macrocycle, is able to deliver an ample family of N-heterocyclic, chiral compounds in high yields and functional group tolerance.
Keyphrases
  • capillary electrophoresis
  • ionic liquid
  • silver nanoparticles
  • molecular dynamics