High Drug Loading Nanoparticles Stabilized with Autologous Serum Proteins Passively Inhibits Tumor Growth.
null MimansaManu JamwalReena DasAsifkhan ShanavasPublished in: Biomacromolecules (2022)
We report drug nanocrystals stabilized with host-specific serum proteins with high loading (∼63% w/w). The human serum derived curcumin nanoparticles (Cur-NanoSera) showed superior in vitro anticancer efficiency compared to a free drug with substantial hemocompatibility. The preadsorbed protein coating impeded further protein corona formation, even with repeated serum exposures. Acute and subacute toxicity evaluations post single and dual injections of C57BL/6 mice indicated that Cur-NanoSera showed no prominent inflammatory response or organ damage in the in-bred mice. Passive accumulation of Cur-NanoSera in tumor tissue significantly suppressed its growth in a syngeneic breast tumor model in addition to controlling tumor burden associated splenomegaly.
Keyphrases
- inflammatory response
- drug induced
- high fat diet induced
- protein protein
- adverse drug
- binding protein
- emergency department
- amino acid
- air pollution
- cell therapy
- skeletal muscle
- platelet rich plasma
- risk factors
- room temperature
- stem cells
- small molecule
- wild type
- lps induced
- mesenchymal stem cells
- acute respiratory distress syndrome
- ionic liquid
- hepatitis b virus