Pharmacogenomics of statin-related myopathy: Meta-analysis of rare variants from whole-exome sequencing.
James S FloydKatarzyna M BlochJennifer A BrodyCyrielle MaroteauMoneeza K SiddiquiRichard GregoryDaniel F CarrMariam MolokhiaArthur L BeaudetJoshua C BisAmmar AhmedXuan LiuPär HallbergQun-Ying YuePatrik K E MagnussonDiane BrissonKerri L WigginsAlanna C MorrisonEtienne KhouryPaul McKeigueBruno H StrickerMaryse Lapeyre MestreSusan R HeckbertArlene M GallagherHector ChinoyRichard A GibbsEmmanuelle Bondon-GuittonRussell TracyEric BoerwinkleDaniel GaudetAnita ConfortiTjeerd van StaaColleen M SitlaniKenneth M RiceAnke-Hilse Maitland-van der ZeeMia WadeliusAndrew P MorrisMunir PirmohamedColin A N PalmerBruce M PsatyAna Alfirevicnull nullPublished in: PloS one (2019)
In this large whole-exome sequencing study of severe statin-related muscle injury conducted to date, we did not find evidence that rare coding variants are responsible for this adverse drug reaction. Larger sample sizes would be required to identify rare variants with small effects, but it is unclear whether such findings would be clinically actionable.