Meta-analysis of gene-environment-wide association scans accounting for education level identifies additional loci for refractive error.
Qiao FanVirginie J M VerhoevenRobert WojciechowskiVeluchamy A BarathiPirro G HysiJeremy A GuggenheimRené HöhnVeronique VitartAnthony P KhawajaKenji YamashiroS Mohsen HosseiniTerho LehtimäkiYi LuToomas HallerJing XieCécile DelcourtMario PirastuJuho WedenojaPuya GharahkhaniCristina VenturiniMasahiro MiyakeAlex W HewittXiaobo GuoJohanna MazurJenifer E HuffmanKatie M WilliamsOzren PolasekHarry CampbellIgor RudanZoran VatavukJames F WilsonPeter K JoshiGeorge McMahonBeate St PourcainDavid M EvansClaire L SimpsonTae-Hwi Schwantes-AnRobert P IgoAlireza MirshahiAudrey Cougnard-GregoireCéline BellenguezMaria BlettnerOlli RaitakariMika KähönenIlkka SeppalaTanja ZellerThomas Meitingernull nullJanina S RiedChristian GiegerLaura PortasElisabeth M van LeeuwenNajaf AminAndré G UitterlindenFernando RivadeneiraAlbert HofmanJohannes R VingerlingYa Xing WangXu WangEileen Tai-Hui BohM Kamran IkramCharumathi SabanayagamPreeti GuptaVincent TanLei ZhouCandice E H HoWan'e LimRoger W BeuermanRosalynn SiantarE-Shyong TaiEranga VithanaEvelin MihailovChiea-Chuen KhorCaroline HaywardRobert N LubenPaul J FosterBarbara E K KleinRonald KleinHoi-Suen WongPaul MitchellAndres MetspaluTin AungTerri L YoungMingguang HeOlavi PärssinenCornelia M van DuijnJie Jin WangCathy WilliamsJost Bruno JonasYik-Ying TeoDavid A MackeyKonrad OexleNagahisa YoshimuraAndrew D PatersonNorbert PfeifferTien-Yin WongPaul N BairdDwight StambolianJoan E Bailey WilsonChing-Yu ChengChristopher J HammondCaroline C W KlaverSeang-Mei SawJugnoo S RahiJean-François KorobelnikJohn P KempNicholas J TimpsonGeorge Davey SmithJamie E CraigKathryn P BurdonRhys D FogartySudha K IyengarEmily ChewSarayut JanmahasatianNicholas G MartinStuart MacGregorLiang XuMaria SchacheVinay NangiaSonghomitra Panda-JonasAlan F WrightJeremy R FondranJonathan H LassSheng FengJing Hua ZhaoKay-Tee KhawNick J WarehamTaina RantanenJaakko KaprioChi Pui PangLi Jia ChenPancy O TamVishal JhanjiAlvin L YoungAngela DöringLeslie J RaffelMary-Frances CotchXiaohui LiShea Ping YipMaurice K H YapGinevra BiinoSimona VaccargiuMaurizio FossarelloBrian FleckSeyhan YazarJan Willem L TidemanMilly TedjaMargaret M DeangelisMargaux MorrisonLindsay FarrerXiangtian ZhouWei ChenNobuhisa MizukiAkira MeguroKari Matti MäkeläPublished in: Nature communications (2016)
Myopia is the most common human eye disorder and it results from complex genetic and environmental causes. The rapidly increasing prevalence of myopia poses a major public health challenge. Here, the CREAM consortium performs a joint meta-analysis to test single-nucleotide polymorphism (SNP) main effects and SNP × education interaction effects on refractive error in 40,036 adults from 25 studies of European ancestry and 10,315 adults from 9 studies of Asian ancestry. In European ancestry individuals, we identify six novel loci (FAM150B-ACP1, LINC00340, FBN1, DIS3L-MAP2K1, ARID2-SNAT1 and SLC14A2) associated with refractive error. In Asian populations, three genome-wide significant loci AREG, GABRR1 and PDE10A also exhibit strong interactions with education (P<8.5 × 10(-5)), whereas the interactions are less evident in Europeans. The discovery of these loci represents an important advance in understanding how gene and environment interactions contribute to the heterogeneity of myopia.
Keyphrases
- genome wide
- systematic review
- case control
- dna methylation
- copy number
- public health
- healthcare
- genome wide association study
- quality improvement
- meta analyses
- endothelial cells
- cataract surgery
- small molecule
- computed tomography
- long non coding rna
- optic nerve
- cell proliferation
- risk factors
- high throughput
- induced pluripotent stem cells
- risk assessment